Patient Survey in Medical Practices on their Visit during the SARS-CoV-2 Pandemic.

Background: Since the beginning of the SARS-CoV2 pandemic medical practices have implemented diverse protective measures to contain the pandemic, practice organization and structures were adapted. In order to get information about patients' perception of their doctors' visit during the pandemic, we conducted a patient survey in medical practices. Method(s): Cross-sectional study of 58 patients, who were interviewed in four medical practices (family physicians and specialists) in the South West of Munich from 02.04.-17.04.2020 on the following topics: "personal risk assessment", "sense of security and perception of protection measures in the practice setting", "importance of the doctor's visit" and "change of medication, nicotine consumption". By means of a questionnaire with 24 items, data were collected anonymously. Results are presented descriptively and via ANOVA as well as via linear regression. Result(s): The personal risk assessments for COVID-19-disease and for a severe course of COVID-19 were rated low moderate, independent of sex or age. Around 8% of the surveyed patients discussed their personal risk with their doctors. The sense of security in the practice setting was rated high. The rating of the protection equipment was good as well, and closely met expectations. The personal importance of the visit varied. Only 6% had considered cancelling their visit beforehand. A change of medication due to SARS-CoV-2 pandemic was not observed. Conclusion(s): The patient survey provides a snapshot of the outpatient setting from the patient's perspective in a hyperdynamic pandemic situation. Yet, due to the small study population, the results have to be interpreted with caution.Copyright © 2021, Deutscher Arzteverlag.

Continuing work in times of COVID-19: Protection measures in the workplace for health professionals.

BACKGROUND: The arrival of COVID-19 in Brazil and the accelerated process of dissemination/contamination added to the evolution of the clinical picture of the disease, and the saturation of the capacity of health services, creating new challenges for researchers, governments, and professionals involved in the occupational health area. OBJECTIVE: This article aims to systematize and synthesize the proposals adopted by the legislation and by the Brazilian State, with a focus on worker protection and guaranteeing a safe work environment for the performance of their professional activities. METHODS: This is qualitative bibliographical research of the narrative literature review type, developed from October 2020 to June 2021 in legislation databases using the strategy: "COVID-19" AND "coronavirus/coronavirus" AND "worker health" on official Brazilian government websites. RESULTS: The lack of an emergency plan for efficient actions to respond to the epidemic caused and is still causing the daily deaths of workers. CONCLUSION: There is a need to guarantee the effectiveness of national and international policies and norms that have been neglected by the Brazilian government.

University Students' Risk Perception, Protective Measures, and General Health During the COVID-19 Pandemic in Turkey.

OBJECTIVE: This study aimed to investigate university students' risk perception, protective measures, and general health during the coronavirus disease 2019 (COVID-19) pandemic in Turkey. METHODS: The research sample consisted of 1920 university students. The data were collected through an online questionnaire. RESULTS: A total of 56.6% of the students considered their risk of being infected with the COVID-19. The number of measures taken by students was lower than expected. Students' increased anxiety perceived individual risk level, insufficient social support perceptions, and their perceptions of the current pandemic more serious than previous epidemics affect the number of measures they take. Students had sleep and study problems, and suicidal thoughts in the social isolation period. Sex, studying in medicine, anxiety related to COVID-19, feeling unconfident in coping with the pandemic, social support, were determined to be risk factors regarding general health, sleep and study problems, and suicidal thoughts. CONCLUSIONS: The results of the study showed that the measures taken by university students were insufficient and the precautions were affected by many factors. It was determined that their health was adversely affected by the pandemic. University administrations and decision-makers should consider the risk factors to improve the students' experiences in such pandemics and emergencies.

A Model to Detect Face Mask Using Deep Learning

Coronavirus pandemic started spreading in 2019 and is still spreading until now in 2021 all over the world. Due to this the healthcare sectors are going on crisis all over the world. One basic protective measure that we can implement in our daily life is wearing a face mask. Wearing a mask properly can control the spread of this virus to a great extent. Various regions have made wearing face mask mandatory to prevent spread of this virus. In this paper we have proposed a deep learning-based model to detect face mask using python, OpenCV, TensorFlow and it can be used in our health care sectors. © 2022 IEEE.

Knowledge and Practice of Personal Protective Measures Against COVID-19 in Africa: Systematic Review.

BACKGROUND: With COVID-19 being a newly evolving disease, its response measures largely depend on the practice of and compliance with personal protective measures (PPMs). OBJECTIVE: This systematic review aimed to examine the knowledge and practice of COVID-19 PPMs in African countries as documented in the published literature. METHODS: A systematic search was conducted on the Scopus, PubMed, and Web of Science databases using appropriate keywords and predefined eligibility criteria for the selection of relevant studies. Only population-based original research studies (including qualitative, quantitative, and mixed methods studies) conducted in Africa and published in the English language were included. The screening process and data extraction were performed according to a preregistered protocol in PROSPERO (CRD42022355101) and followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The quality of the included studies was assessed using the Mixed Methods Appraisal Tool. Thematic analysis was used to systematically summarize the studies into 4 predefined domains: knowledge and perception of PPMs, mask use, social and physical distancing, and handwashing and hand hygiene, including their respective levels and associated factors. RESULTS: A total of 58 studies across 12 African countries were included, published between 2019 and 2022. African communities, including various population groups, had varying levels of knowledge and practice of COVID-19 PPMs, with the lack of personal protective equipment (mainly face masks) and side effects (among health care workers) being the major reasons for poor compliance. Lower rates of handwashing and hand hygiene were particularly noted in several African countries, especially among low-income urban and slum dwellers, with the main barrier being the lack of safe and clean water. Various cognitive (knowledge and perception), sociodemographic, and economic factors were associated with the practice of COVID-19 PPMs. Moreover, there were evident research inequalities at the regional level, with East Africa contributing 36% (21/58) of the studies, West Africa contributing 21% (12/58), North Africa contributing 17% (10/58), Southern Africa contributing 7% (4/58), and no single-country study from Central Africa. Nonetheless, the overall quality of the included studies was generally good as they satisfied most of the quality assessment criteria. CONCLUSIONS: There is a need to enhance local capacity to produce and supply personal protective equipment. Consideration of various cognitive, demographic, and socioeconomic differences, with extra focus on the most vulnerable, is crucial for inclusive and more effective strategies against the pandemic. Moreover, more focus and involvement in community behavioral research are needed to fully understand and address the dynamics of the current pandemic in Africa. TRIAL REGISTRATION: PROSPERO International Prospective Register of Systematic Reviews CRD42022355101; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022355101.

SAPV patients in the COVID-19 crisis: An interview-based study of palliative care patients' experiences.

Background: In the outpatient setting, COVID-19 primarily affects palliative care patients who receive care as part of specialized outpatient palliative care (SAPV). To prevent infections, the implementation of new safety precautions and telemedical communication options in the SAPV participating in the study became necessary. Objective(s): This study examines the impact of the COVID-19 pandemic on palliative care patients' personal and social problems and their experiences with caregiving SAPV. Material(s) and Method(s): A total of 20 SAPV patients were interviewed about their problems in relation to the pandemic and about their experiences with care provided by SAPV in semi-structured phone interviews. Result(s): Fear of loneliness and infection weigh heavily on palliative care patients. Most patients wanted to avoid hospitalization due to increased risk of infection. Protective measures of SAPV gave them a sense of security and were accepted despite restrictions on personal contact. Modern forms of communication were useful but could not replace personal contact. Conclusion(s): The pandemic led to changes in SAPV and had an impact on the social environment of palliative care patients. Protective measures are important for the sense of security of palliative care patients under care. The quality of care provided by the SAPV structure adapted to COVID-19 is usually not perceived by patients as having deteriorated. Fears of social isolation are highly valued by palliative care patients and can be reduced by SAPV. Personal contact with SAPV cannot be replaced by modern communication options, although patients do accept telemedicine as an "emergency solution".Copyright © 2022, The Author(s).

Computational Fluid Dynamics-Based Optimization of Face Mask Filter Media Using Micro-Computed Tomography Scans

During the COVID-19 pandemic, face masks have become an important protective measure for reducing the spread of potentially infectious aerosol particles emitted while speaking, coughing, or simply breathing. In this work, a voxel-based numerical model obtained from micro-computed tomography (microCT) scans of a medical mask was validated by comparing fractional filtration efficiency and net pressure loss to values measured at an in-house mask test bench after discharging the mask in isopropanol. Varying mean fiber diameter, solid volume fraction, and thickness of the filter medium, parametric studies based on a digital twin of the mask sample were carried out. It is demonstrated that face masks can be designed where filtration efficiency, pressure drop, and material consumption is improved compared to the base case. © 2023 The Authors. Chemical Engineering Technology published by Wiley-VCH GmbH.

Modeling and interactive simulation of measures against infection transmission

In this paper we develop an approach to modeling and simulating the process of infection transmission among individuals and the effectiveness of protective counter-measures. We base our approach on pedestrian dynamics and we implement it as an extension of the Vadere simulation framework. In order to enable a convenient simulation process for a variety of scenarios, we allow the user to interact with the simulated virtual environment (VE) during run time, for example, by dynamically opening/closing doors for room ventilation and moving/stopping agents for re-positioning their locations. We calibrate and evaluate our approach on a real-life case study—simulating COVID-19 infection transmission in two kinds of scenarios: large-scale (such as the city of Münster, Germany) and small-scale (such as the most common indoor environments—classrooms, restaurants, etc.). By using the tunable parameters of our modeling approach, we can simulate and predict the effectiveness of specific anti-COVID protective measures, such as social distancing, wearing masks, self-isolation, schools closing, etc. [ FROM AUTHOR] Copyright of Simulation is the property of Sage Publications, Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

How big of an impact do asymptomatic people have on the dynamics of an epidemic?

Asymptomatic carriers serve as a potential source of transmission of epidemic diseases. Exposed people who develop symptoms only get tested and remain isolated in their homes or sometimes in hospitals when needed. In contrast, the asymptomatic individuals go untested and spread the disease silently as they roam freely throughout their entire infectious lifetime. The work intends to explore the role of asymptomatic carriers in the transmission of epidemic diseases and investigate suitable optimal control strategies. We propose a SEIAQR compartmental model subdividing the total population into six different compartments. To illustrate the model's implication, we estimate the number of asymptomatic individuals using COVID-19 data during June 9–July 18, 2021 from Bangladesh. We then analyze the model to explore whether the epidemic subsides if the asymptomatic individuals are tested randomly and isolated. Finally, to gain a better understanding of the potential of this unidentified transmission route, we propose an optimal control model considering two different control strategies: personal protective measures and isolation of asymptomatic carriers through random testing. Our results show that simultaneous implementation of both control strategies can reduce the epidemic early. Most importantly, sustained effort in identifying and isolation of asymptotic individuals allows relaxation in personal protective measures. © 2023

Comparative Performance Evaluation of Personal Protective Measures and Antiviral Agents Against SARS-CoV-2 Variants: A Narrative Review.

Scientists identified SARS-CoV-2 in December 2019 in Wuhan city of China. Soon after its identification, Covid-19 spreads almost everywhere. The World Health Organization (WHO) declared the Covid-19 outbreak as a pandemic on March 11, 2020. Countries are facing multiple waves due to the different variants of the coronavirus. Personal preventive measures, vaccines, and antiviral drugs are the approaches to control Covid-19. However, these approaches are being implemented in different countries at different levels because of the availability of personal protective measures and antiviral agents. The objective of this study was to evaluate the effectiveness of practicing measures to fight the Covid-19 pandemic. Here we searched relevant literature from PubMed and Scopus using the keywords such as personal protective measures, antiviral agents, and vaccine effectiveness. According to the present findings, protective measures were found comparatively less effective. Nevertheless, these measures can be used to limit the spreading of Covid-19. Antiviral agents can reduce the hospitalization rate and are more effective than personal protective measures. The most effective strategy against Covid-19 is early vaccination or multiple vaccination dose. The respective authorities should ensure equal distribution of vaccines, free availability of antiviral drugs, and personal protective measure in poor and developing countries. We recommend more studies to describe the effectiveness of practicing preventive measures and antiviral agents against recent variants of the coronavirus.

Laser-Induced Smoke in Dermatologic Practice: A Survey to Explore Hazard Perceptions, Safety Measures and Unmet Needs.

Introduction: Inhalation of laser-induced smoke is a potential health hazard to exposed physicians and laser operators. To date, little is known about the perception of health hazards related to laser-induced smoke exposure among physicians and the actual use of safety measures to mitigate these risks. Methods: In May 2020, 514 members of the European Society for Lasers and Energy-Based Devices (ESLD) were invited by email to participate in an online survey. The survey comprised 16 questions including multiple-choice and open-ended questions. Results: Responses were received from 109 participants. The majority (90%) were aware of potential hazards and highlighted a desire for better protective measures (60%). A smoke evacuation system was frequently used with ablative lasers (66%) and fractional ablative lasers (61%), but less the case with non-ablative lasers (30%) and hair removal lasers (28%). The COVID-19 outbreak had no clear effect on the use of smoke evacuation systems. Prior to the COVID-19 outbreak, mainly surgical masks were used (40-57%), while high filtration masks (FFP1, FFP2 or FFP3) were used by only a small percentage (15-30%). Post COVID-19 outbreak, the use of high filtration masks increased significantly (54-66%), predominately due to an increase in the use of FFP2 masks. Reasons mentioned for inadequate protective measures were sparse knowledge, limited availability, discomfort, excessive noise, high room temperatures, and financial costs. Conclusion: While there is considerable awareness of the hazards of laser-induced smoke among physicians and laser operators, a substantial number of them do not use appropriate protective measures. The implementation of regulations on safety measures is hampered by sparse knowledge, limited availability, discomfort, excessive noise, financial issues, and high room temperatures.

Relationship between the government implemented protective measures for coronavirus disease 2019 (COVID-19) during the pandemic and the understanding of religious evidence in Muslim community: A cross-sectional study from Saudi Arabia.

BACKGROUND: Coronavirus disease 2019 (COVID-19), which has swept across the Middle East has ignited religious tensions. Although the implementation of effective preventive measures is the best way to control the spread of COVID-19, in such countries as Saudi Arabia, these restrictions have sometimes been viewed as violations of religious practice. The present study explores the reasons for ignoring the authorities' recommendations, and the inability of the authorities to create a sense of inclusion in the protective measures they introduce against the COVID-19 outbreak. MATERIALS AND METHODS: A cross-sectional community-based study was conducted in Saudi Arabia and data were collected from 922 participants. The questionnaire contained 17 questions on personal characteristics, compliance with governmental protective measures, and participants' understanding of religious evidence. The SPSS was used for data analysis. Categorical data was presented as frequencies and percentages. Chi-square test was used to determine the association between people's compliance to the protective measures and their understanding of religious evidence. RESULTS: The age of the study participants ranged between 17 to 68 years with a mean age of 43.9 (±12.69) years. About half of the participants reported always complying to Mosque precautions (49.9%) and keeping distance (53.7%). However, only 34.3% participants always maintained social distancing while visiting relatives; about 25.2% often kept a social distance. We found that an adequate understanding of religious principles was significantly associated with accepted overall commitment, and inadequate understanding was significantly associated with lack of commitment. An adequate understanding of religious principles was significantly associated with a positive attitude toward future commitment and inadequate understanding was significantly associated with a negative attitude. CONCLUSION: We recommend that the Ministry of Health in Saudi Arabia solicits the support of religious scholars to give a proper explanation of the religious evidence and eliminate misconceptions to promote compliance with the protective measures.

Effect of Protective Measures Adopted in the COVID-19 Pandemic on Hemodialysis Patients.

Introduction The use of masks and other preventive measures is nowadays an essential measure to prevent COVID-19 infections, particularly in hemodialysis patients. The aim of this study was to understand whether these protective measures adopted during the COVID-19 pandemic reduced or somehow contained the number of respiratory infections in a population of hemodialysis patients. Methods This was a longitudinal retrospective single-center study of hemodialysis patients with at least six months of follow-up in a central hospital. A total of 103 patients were evaluated for the study. Two groups were defined: a control group that was followed in the year before the beginning of the pandemic and a group that followed in the year after its beginning. Results Patients in the pandemic group had a higher prevalence of previous major cardiovascular events (48.9% vs 8.6%) and heart failure (31.3% vs 12.1%) than those in the control group. Vaccination rates for influenza and pneumococcus as well as the monthly analytical results were similar in both groups. There were no significant differences in lower respiratory infections, hospitalizations caused by lower respiratory infections, and mortality between both groups. However, not accounting for aspiration pneumonias, the pandemic group had half the mortality due to respiratory infections (2.2% vs 5.2%). Conclusion Despite patients in the pandemic group having a similar prevalence of respiratory infections and hospitalizations motivated by lower respiratory infections, they presented about half the mortality of the control group. This suggests that although there was no decrease in the number of infections, protective measures may have contributed to a decreased mortality.

The IMU Augment SLAM on Unmanned Vehicle for Detection of Protective Measures in COVID-19

Detecting protective measures (e.g., masks, goggles and protective clothing) is a momentous step in the fight against COVID-19. The detection mode of unmanned devices based on Simultaneous localization and mapping (SLAM) and fusion technology is more efficient, economical and safe than the traditional manual detection. In this paper, a tightly-coupled nonlinear optimization approach is used to augment the visual feature extraction of SLAM by the gyroscope of the IMU to obtain a high-precision visual inertial system for joint position and pose estimation. Based on the VINS-Mono frame, first, an LSD algorithm based on a conditional selection strategy is proposed to extract line features efficiently. Then, we propose recovering missing point features from line features. Moreover, we propose a strategy to recover vanishing point features from line features, and add residuals to the SLAM cost function based on optimization, which optimizes point-line features in real time to promote the tracking and matching accuracy. Second, the wavelet threshold denoising method based on the 3σ criterion is used to carry out real-time online denoising for gyroscope to improve the output precision. Our WD-PL-VINS was measured on publicly available EuRoC datasets, TUM VI datasets and evaluated and validated in lab testing with a unmanned vehicle (UV) based on the NVIDIA Jetson-TX2 development board. The results show that our method's APE and RPE on MH-03-easy sequences are improved by 69.28% and 97.66%, respectively, compared with VINS-Mono. © 2001-2012 IEEE.

Coping with a lack of evidence: living-donor kidney transplantation in the initial phase of the SARS-CoV-2 pandemic.

Due to immunosuppressive therapy, transplant patients are more susceptible to viral and bacterial infections. A potentially deadly new virus haunted us in 2020: SARS-CoV­2, causing coronavirus disease 19 (COVID-19). We analyzed the consequences of this previously unknown risk for our living-donor transplant program in the first year of the pandemic. After the complete lockdown in spring 2020, our transplant center in Linz resumed the living-donor kidney transplantation program from June to September 2020, between the first and second waves of COVID-19 in Austria. We compared the outcomes of these living-donor kidney transplantations with the transplant outcomes of the corresponding periods of the three previous years. From June 4 to September 9, 2020, five living-donor kidney transplantations were performed. All donors and recipients were screened for COVID 19 infection by PCR testing the day before surgery. Kidney transplant recipients remained isolated in single rooms until discharge from hospital. All recipients and donors remained SARS-CoV­2 negative during the follow-up of 10 months and have been fully vaccinated to date. The number of living transplants in the studied period of 2020 was constant compared to the same months of 2017, 2018, and 2019. Living-donor kidney transplantation can be continued using testing for SARS-CoV­2 and meticulous hygienic precautions in epidemiologically favorable phases of the SARS-CoV­2 pandemic. Donors and recipients should be carefully selected and informed about risks and benefits.

A model for the early COVID-19 outbreak in China with case detection and behavioural change

We investigate a model of the early stage of the COVID-19 epidemic comprising undetected infected individuals as well as behavioural change towards the use of self-protection measures. The model is fitted to China data reported between 22 January and 29 June 2020. Using fitting results, we then consider model responses to varying screening intensities. © 2022 Julien Arino, Khalid El Hail, Mohamed Khaladi, Aziz Ouhinou.

COVID-19 Risk Perception and Adherence to Preventive Measures among Medical Students after Receiving COVID-19 Vaccination: A Multicenter Cross-Sectional Study in Egypt.

This study aimed to assess the perception of COVID-19 risk and the adherence to protective measures among medical students after vaccination. We conducted a cross-sectional survey on a convenience sample of students from all the 18 governmental medical schools in Egypt. A total of 2273 students participated in the online self-administered questionnaire. Around 8 in 10 (83.2%) students were fully vaccinated, of which 17.9% received the booster dose. Only 36.9% believed that COVID-19 is serious on the individual level. The majority (73.9%) strongly or slightly agreed they may become infected after vaccination if they do not follow the preventive measures. We observed a slow decline in the perceived risk of vulnerability and susceptibility to COVID-19 infection among students in parallel to a growing perception of self-efficacy and controllability. Less than one-third (28.9%) of students showed good adherence to protective measures. However, this was lower than the previously reported adherence in the same population before vaccination. Female students, those in the first academic year, those who did not contract COVID-19 infection before, and those with a higher perception of susceptibility and perceived controllability were more likely to perform better at protective measures.

A First Attempt at Unreliable News Detection in Swedish

Throughout the COVID-19 pandemic, a parallel infodemic has also been going on such that the information has been spreading faster than the virus itself. During this time, every individual needs to access accurate news in order to take corresponding protective measures, regardless of their country of origin or the language they speak, as misinformation can cause significant loss to not only individuals but also society. In this paper we train several machine learning models (ranging from traditional machine learning to deep learning) to try to determine whether news articles come from either a reliable or an unreliable source, using just the body of the article. Moreover, we use a previously introduced corpus of news in Swedish related to the COVID-19 pandemic for the classification task. Given that our dataset is both unbalanced and small, we use subsampling and easy data augmentation (EDA) to try to solve these issues. In the end, we realize that, due to the small size of our dataset, using traditional machine learning along with data augmentation yields results that rival those of transformer models such as BERT. © European Language Resources Association (ELRA), licensed under CC-BY-NC-4.0.

Current state of findings on the mechanisms of SARS-CoV-2 transmission and the efficacy of preventive measures in enclosed spaces with special focus on aerosols - A systematic review

Since the SARS-CoV-2 coronavirus epidemic originating from Wuhan and spreading to other places in China, has developed into a pandemic in the first months of this year, surface transmission and transmission through respiratory droplets with a typical diameter of about 50 mum to 1 mm, produced when an infected person coughs, sneezes or talks, have been considered the main modes of transmission for COVID-19. Advice as to maintain a good social distance of 1.5 to 2 meters, and the obligation to wear a mask to greatly reduce the speed of infectious droplets when coughing, sneezing and speaking and thus to minimize the "range" of infectious material aimed at minimizing these modes of infection route as much as possible. An increasing body of evidence that the transmission through (much) smaller infectious particles, so-called aerosols, could be another important mode of transmission, together with (also empirical) evidence of real life effectiveness of those strategies demand for a reappraisal of the actual risk reduction due to commonly recommended individual and population based protective measures. Only prioritizing of and restricting to regulations justified by reasonably reliable evidence may prevent currently required hygiene concepts from leading to quantitatively escalating self-restrictions in service, trade and commerce, which may jeopardize economic survival of the society at large. The present review aims at drawing upon the current best evidence concerning SARS-CoV-2 and COVID-19, and the respective search strategy suggested by Pubmed as of May 28, 2020 (https://www.ncbi.nlm.nih.gov/sars-cov-2) to support developing effective and efficient hygiene concepts and their appraisal. Copyright © VERLAG PERFUSION GMBH.

Chronic obstructive pulmonary disease and COVID-19

Recently, single studies have described the picture of COVID-19 in patients with chronic obstructive pulmonary disease (COPD). Further study of this comorbid condition will help to assess the course and prognosis of each condition correctly, develop an effective plan for the management of patients with COPD during the pandemic caused by SARS-CoV-2 infection. The aim. The article is an analytical review of the scientific literature from PubMed, Google Scholar, medRxiv, bioRxiv in order to study the clinical features of COVID-19 in patients with COPD. The published studies of the new coronavirus infection showed that patients with COPD account for 2% among those infected with SARS-CoV-2. However, further studies are needed to study the course of COVID-19 in patients with COPD. The conducted studies indicate a high level of ACE2 receptors to SARS-CoV-2 in current smokers and patients with COPD, which may explain the easier penetration of SARS-CoV-2 into the host organism and the severe course of the disease in this population. Conclusion. Although a number of clinical studies strongly suggest that men have more severe COVID-19 than women, the patient's gender is not always taken into account. It is possible that the more severe course of COVID-19 is associated with the increased prevalence of smoking and COPD in men as compared to women to a lesser extent than with the high production of testosterone and X-linked inheritance of the androgen gene and the ACE2 gene. Copyright © 2022 Medical Education. All rights reserved.